Steve Rogers, a rejected military soldier, transforms into Captain America after taking a dose of a "Super-Soldier serum". But being Captain America comes at a price as he attempts to take down a warmonger and a terrorist organization.

A dying CIA agent trying to reconnect with his estranged daughter is offered an experimental drug that could save his life in exchange for one last assignment.

It is 1942, America has entered World War II, and sickly but determined Steve Rogers is frustrated at being rejected yet again for military service. Everything changes when Dr. Erskine recruits him for the secret Project Rebirth. Proving his extraordinary courage, wits and conscience, Rogers undergoes the experiment and his weak body is suddenly enhanced into the maximum human potential. When Dr. Erskine is then immediately assassinated by an agent of Nazi Germany's secret HYDRA research department (headed by Johann Schmidt, a.k.a. the Red Skull), Rogers is left as a unique man who is initially misused as a propaganda mascot; however, when his comrades need him, Rogers goes on a successful adventure that truly makes him Captain America, and his war against Schmidt begins.