Special Agent Leon S.Kennedy goes against his superior's orders and works to destroy a series of biological weapons being used in a war zone in Europe.

U.S. federal agent Leon S. Kennedy sneaks into the "East Slavic Republic" to verify rumors that Bio-Organic Weapons (BOWs) are being used in the country's civil war, which the U.S. and Russia are making preparations to jointly intervene in. Right after his infiltration, the U.S. government orders him to leave immediately. Determined to uncover the truth, Leon ignores the order and enters the battlefield to end the chain of tragedies caused by the BOWs.

United States Special Agent Leon S. Kennedy sneaks into a small Eastern European country to verify rumors that Bio Organic Weapons (B.O.W.s) are being used in war. Right after his infiltration, the U.S. government orders him to leave immediately. Determined to uncover the truth, Leon ignores the order and enters the battlefield to end the chain of tragedies caused by the B.O.W.s.

High school student Ling Xiaoyu is recruited by Anna Williams of G Corporation to transfer to Kyoto University and gather information on a student named Shin Kamiya. Meanwhile, Jin Kazama, the current head of the Mishima Zaibatsu, sends Alisa Bosconovitch to the university for the same mission. Though they do not know each other's true motives, Xiaoyu and Alisa become close friends. However, their friendship is put to the test when Shin is captured by an unknown assailant.