While investigating the murder of a family, Sheriff Sheldon and his team are puzzled with the discovery of the body of a stranger buried in the basement that does not fit to the crime scene. He brings the corpse of the beautiful Jane Doe late night to the coroner Tommy Tilden and requests to have the cause of death until the next morning to have an answer to the press. Tommy's son and assistant Austin Tilden is ready to go to the movie theater with his girlfriend Emma, but he decides to stay to help his father in the autopsy. Along the stormy and tragic night, they disclose weird and creepy secrets about Jane Doe.

Cox and Hirsch play father and son coroners who receive a mysterious homicide victim with no apparent cause of death. As they attempt to identify the beautiful young "Jane Doe," they discover increasingly bizarre clues that hold the key to her terrifying secrets.