Mourning his dead son, a haunted Vietnam War veteran attempts to uncover his past while suffering from a severe case of dissociation. To do so, he must decipher reality and life from his own dreams, delusions, and perceptions of death.

After returning home from the Vietnam War, veteran Jacob Singer struggles to maintain his sanity. Plagued by hallucinations and flashbacks, Singer rapidly falls apart as the world and people around him morph and twist into disturbing images. His girlfriend, Jezzie, and ex-wife, Sarah, try to help, but to little avail. Even Singer's chiropractor friend, Louis, fails to reach him as he descends into madness.

In 1974 New York, 50-year-old Chris (Clive Owen) has just been released on good behavior after several years in prison following a gangland murder. Reluctantly waiting for him outside the gates is his younger brother (Billy Crudup), a cop with a bright future. Chris and Frank have always been different, and their father, Leon (James Caan), who raised them alone, seems to favor Chris despite all his troubles. Yet blood ties are the ones that bind, and Frank, hoping that his brother has changed, is willing to give him a chance - he shares his home, finds him a job, and helps him reconnect with his children and his ex-wife, Monica (Marion Cotillard). But Chris' inevitable descent back into a life of crime proves to be the last in a long line of betrayals, and after his brother's latest transgressions, Frank banishes him from his life. But it's already too late, as the brothers' destiny is bound together, forever.

A newly elected District Attorney finds himself in the middle of a police corruption investigation that may involve his father and his partner.

The story of Henry Hill and his life in the mob, covering his relationship with his wife Karen Hill and his mob partners Jimmy Conway and Tommy DeVito in the Italian-American crime syndicate.