Five friends spend one lost weekend in a mix of music, love and club culture.

Based on Patrick DeWitt's novel, The Sisters Brothers revolves around the colorfully named gold prospector Hermann Kermit Warm, who's being pursued across 1000 miles of 1850s Oregon desert to San Francisco by the notorious assassins Eli and Charlie Sisters. Except Eli is having a personal crisis and beginning to doubt the longevity of his chosen career. And Hermann might have a better offer.

Jacq Vaucan is an insurance agent of ROC robotics corporation who investigates cases of robots violating their primary protocols against harming humans. What he discovers will have profound consequences for the future of humanity.