Paul is an actor who feels bogged down by his participation in a production of Chekov's play, Vanya.

Three stories about the world of opioids collide: a drug trafficker arranges a multi-cartel Fentanyl smuggling operation between Canada and the U.S., an architect recovering from an OxyContin addiction tracks down the truth behind her son's involvement with narcotics, and a university professor battles unexpected revelations about his research employer, a drug company with deep government influence bringing a new "non-addictive" painkiller to market.

Follows lonely bartender Bob Saginowski through a covert scheme of funneling cash to local gangsters - "money drops" - in the underworld of Brooklyn bars. Under the heavy hand of his employer and cousin Marv, Bob finds himself at the center of a robbery gone awry and entwined in an investigation that digs deep into the neighborhood's past where friends, families, and foes all work together to make a living - no matter the cost.