A New York schoolteacher experiences a midlife crisis when, in quick succession, her husband leaves, her adoptive mother dies, and her biological mother, an eccentric talk show host, materializes and turns her life upside down as she begins a courtship with the father of one of her students.

In New York City 1981, an ambitious immigrant fights to protect his business and family during the most dangerous year in the city's history.

A desperate man takes part in an underworld game of Russian roulette.

In 1970s Los Angeles, a mismatched pair of private eyes investigate a missing girl and the mysterious death of a porn star.

In 1974 New York, 50-year-old Chris (Clive Owen) has just been released on good behavior after several years in prison following a gangland murder. Reluctantly waiting for him outside the gates is his younger brother (Billy Crudup), a cop with a bright future. Chris and Frank have always been different, and their father, Leon (James Caan), who raised them alone, seems to favor Chris despite all his troubles. Yet blood ties are the ones that bind, and Frank, hoping that his brother has changed, is willing to give him a chance - he shares his home, finds him a job, and helps him reconnect with his children and his ex-wife, Monica (Marion Cotillard). But Chris' inevitable descent back into a life of crime proves to be the last in a long line of betrayals, and after his brother's latest transgressions, Frank banishes him from his life. But it's already too late, as the brothers' destiny is bound together, forever.

Family-patriarch Jack Byrnes wants to appoint a successor. Does his son-in-law, the male nurse Greg Focker, have what it takes?