Engaged in a mysterious relationship with her dead best friend from the Army, a female Afghanistan veteran comes head to head with her Vietnam vet grandfather at the family's ancestral lake house.

The Curtis' family is selected to test a new home device: a digital assistant called AIA. AIA learns the family's behaviors and begins to anticipate their needs. And she can make sure nothing - and no one - gets in her family's way.

In San Francisco, Jill Valentine is dealing with a zombie outbreak and a new T-Virus, Leon Kennedy is on the trail of a kidnapped DARPA scientist, and Claire Redfield is investigating a monstrous fish that is killing whales in the bay. Joined by Chris Redfield and Rebecca Chambers, they discover the trail of clues from their separate cases all converge on the same location, Alcatraz Island, where a new evil has taken residence and awaits their arrival.