Down-and-out former preacher Bill Hill witnesses stranger Juvenal save a woman from her abusive husband by defusing the latter's anger — and ending his wife's blindness. Determined to profit from Juvenal's mystical powers, Bill asks an old friend, Lynn Faulkner, to sneak into the Alcoholics Anonymous facility where Juvenal works as a counselor, but she finds herself falling for the healer.

After a car crash sends repressed cartoonist Stu Miley (Fraser) into a coma, he and the mischievous Monkeybone, his hilariously horny alter-ego, wake up in a wacked-out waystation for lost souls. When Monkeybone takes over Stu's body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before his sister pulls the plug on reality forever!

In a coma, a cartoonist finds himself trapped within his own underground creation and must find a way to get back, while racing against his popular but treacherous character, Monkeybone.

A video store clerk agrees to have his life filmed by a camera crew for a television show.