After a sudden attack on MI7, Johnny English, Britain's most confident, yet unintelligent spy, becomes Britain's only spy.

Novelist Catherine Tramell is once again in trouble with the law, and Scotland Yard appoints psychiatrist Dr. Michael Glass to evaluate her. Though, like Detective Nick Curran before him, Glass is entranced by Tramell and lured into a seductive game.

Life for former United Nations investigator Gerry Lane and his family seems content. Suddenly, the world is plagued by a mysterious infection turning whole human populations into rampaging mindless zombies. After barely escaping the chaos, Lane is persuaded to go on a mission to investigate this disease. What follows is a perilous trek around the world where Lane must brave horrific dangers and long odds to find answers before human civilization falls.