In 1989, the boy Martin Bristol has congenital insensitivity to pain with anhidrosis (CIPA), a rare neural disorder, in which the patient does not feel pain, heat or cold. He is abducted by the deranged serial-killer Graham Sutter (Brett Rickaby) and brought to the Sutter Meat & Poultry, an abandoned meat-packing plant in Minersville, Pennsylvania, where Graham slaughters young women that he kidnaps. Five years later, the stubborn seventeen year-old teenager Allison Miller loses her parents and moves to her uncle Jonathan Miller's house near the decrepit plant. Jonathan, his wife Karen and their little daughter Wendy welcome Allison, but the teenager does not give much attention to her new family. Allison likes to run alone on the road and she passes by the meat-packing plant and then she meets the mechanic William "Billy" and has a crush on him. Jonathan advises Allison to avoid running near the old factory and Billy, who is a problematic teenager. Allison does not listen to her ...

After a stint in a mental institution, former teacher Pat Solitano moves back in with his parents and tries to reconcile with his ex-wife. Things get more challenging when Pat meets Tiffany, a mysterious girl with problems of her own.