When an unseen enemy threatens mankind by taking over their bodies and erasing their memories, Melanie Stryder risks everything to protect the people she cares about.

The son of a slain NYPD officer joins the force, where he falls in with his father's former partner and a team of rogue cops.

After a couple of weeks seeking out his teenage daughter Maggie, Wade finds her in the quarantine wing of a hospital. Maggie has been infected by a lethal outbreak that transforms the victim into a zombie. Wade's friend Dr. Vern Kaplan releases Maggie to spend her last days with Wade and her family. Her stepmother Caroline asks Wade to take their little kids to her sister's house to keep them safe. While Maggie is slowly transformed, Wade stays with her, protecting her. But Dr. Vern warns him that the moment is coming closer and closer when he must make an ultimate decision.

Seventeen year-old Nell Margaret Sweetzer is found completely insane when trying to explain her possession by the demon called Abalam. After medical and psychological treatment, she is sent to the Deveraux transition house in New Orleans managed by Frank Merle, who helps her to start a new life. She finds a job as a hotel housekeeper, befriends her new roommates, and develops a crush on her coworker, Chris. Soon, Nell comes to realize that she is haunted by people from her cult... and by the same evil force that once possessed her. When Nell meets Miss Cecile, she tells Nell that she has been following her since the hospital. Further, she discloses that she belongs to the sect Order of The Right Hand, and that they can protect her from the evil in an attempt to divert the prophecy of an apocalypse. Will Nell accept help, and be protected from the extremely powerful, evil force Abalam -- Or will she come to accept... herself?