Two F.B.I. Agents with wildly different styles arrive in Mississippi to investigate the disappearance of some civil rights activists.

Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.

In a future world devastated by disease, a convict is sent back in time to gather information about the man-made virus that wiped out most of the human population on the planet.

A freak accident brings together a critically ill mathematician, a grieving mother, and a born-again ex-con.

The presidencies of Kennedy and Johnson, the Vietnam War, the Watergate scandal and other historical events unfold from the perspective of an Alabama man with an IQ of 75, whose only desire is to be reunited with his childhood sweetheart.

Amateur sleuth Samantha Kinsey's latest case has her trying to figure out who killed her best friend Barbara after she was left out of her family's will and every one of the family members become suspects.

Barney teaches chemisty, and is planning to abduct a woman. Despite methodical planning and countless trial runs he always manages to mess things up. Then Diane, who is traveling with her boyfriend Jeff, unwittingly makes herself an easy target. The story is mainly from Jeff's viewpoint, as he searches for Diane. Barney watches him.