A New York schoolteacher experiences a midlife crisis when, in quick succession, her husband leaves, her adoptive mother dies, and her biological mother, an eccentric talk show host, materializes and turns her life upside down as she begins a courtship with the father of one of her students.

Mourning his dead son, a haunted Vietnam War veteran attempts to uncover his past while suffering from a severe case of dissociation. To do so, he must decipher reality and life from his own dreams, delusions, and perceptions of death.

An affable underachiever finds out he's fathered 533 children through anonymous donations to a fertility clinic 20 years ago. Now he must decide whether or not to come forward when 142 of them file a lawsuit to reveal his identity.

As a Washington, D.C. psychiatrist unearths the origin of an alien epidemic, she also discovers her son might be the only way it can be stopped.

After returning home from the Vietnam War, veteran Jacob Singer struggles to maintain his sanity. Plagued by hallucinations and flashbacks, Singer rapidly falls apart as the world and people around him morph and twist into disturbing images. His girlfriend, Jezzie, and ex-wife, Sarah, try to help, but to little avail. Even Singer's chiropractor friend, Louis, fails to reach him as he descends into madness.

A Manhattanite book editor finds her take on the game of romance changed after she lures the attention of an influential older man.