The nerds are now in control of the university, as a result of Lewis Skolnick and the rest's actions in the two previous movies. A new generation of sportsmen arrive, however, determined on winning the school back. The principle, himself an ex-nerd fighter, helps them, and the nerds return to suppression. Harold Skolnick needs help from his uncle Lewis, the hero of the first two movies. Lewis, however, are not too proud of his nerd past, and won't reveal any of it, much less help his nephew. However, his wife makes him change his mind, and with help from his friends from the first two movies, they start the fight to win the school back, using classic nerd tricks.

An undercover FBI agent becomes a vigilante and sets out to unleash his wrath upon the corrupt businessman who slaughtered his entire family at a reunion.

Dudley (Booger) Dawson is about to get married, but the father of the bride doesn't want his daughter to marry a nerd. The nerdy gang needs to set things straight once again.

When letters written to God start getting results, and replies, people everywhere are amazed. The post office, however, is annoyed.

A professional karaoke hustler reconnects with his daughter and a bored suburban businessman turns outlaw karaoke singer, among other plotlines.

As part of a fertility research project, a male scientist agrees to carry a pregnancy in his own body.