When three different animals become infected with a dangerous pathogen, a primatologist and a geneticist team up to stop them from destroying Chicago.

In the aftermath of a massive earthquake in California, a rescue-chopper pilot makes a dangerous journey with his ex-wife across the state in order to rescue his daughter.

A brilliant counterterrorism analyst with a deep distrust of AI discovers it might be her only hope when a mission to capture a renegade robot goes awry.

Primatologist Davis (Dwayne Johnson) shares an unshakable bond with George, the extraordinarily intelligent silverback gorilla who has been in his care since he was young. When a greed-fueled corporation's genetic experiment goes awry, George and other animals across the country are mutated into aggressive supercreatures who destroy everything in their path. In this adrenaline-filled ride, Davis tries to find an antidote, not only to halt a global catastrophe but also to save the fearsome creature who was once his friend.