When Katherine, a beautiful Southern girl obsessed with thoughts of eternal life, invites Count Alucard to come to her mansion in the U.S., she unleashes a Pandora's box of horror on unsuspecting relatives and neighbors.

Dr. Alice Dodgson (Jennifer Gray) gets her medical license revoked after the death of a patient. She's facing the possibility of not getting any job when she accepts to be the nurse for one young man who suffers of cephalitis named Wesley Claybourne (Daniel Lapaine). Aside from the sickness from which he's suffering, Wesley believes he has been "touched" by some voodoo cult. While she stays in Jamaica, Dr. Dodgson will feel uncomfortable as she discovers that voodoo is not only a "state of mind", and could be a real threat to her life and Wesley's. She'll have to discover why she and her patient are targets of the voodoo curse.