A teenage fugitive with an incredible secret races to stay one step ahead of the mysterious forces seeking destroy him in this sci-fi action thriller. With three dead and one on the run, the race to find the elusive Number Four begins. Outwardly normal teen John Smith never gets too comfortable in the same identity, and along with his guardian, Henri, he is constantly moving from town to town. With each passing day, John gains a stronger grasp on his extraordinary new powers, and his bond to the beings that share his fantastic fate grows stronger.

Jerry Shaw and Rachel Holloman are two strangers whose lives are suddenly thrown into turmoil by a mysterious woman they have never met. Threatening their lives and family, the unseen caller uses everyday technology to control their actions and push them into increasing danger. As events escalate, Jerry and Rachel become the country's most-wanted fugitives and must figure out what is happening to them.