A former U.S. soldier returns to his hometown to find it overrun by crime and corruption, which prompts him to clean house.

San Francisco police officer Frank Connor is in a frantic search for a compatible bone marrow donor for his gravely ill son. There's only one catch the potential donor is convicted multiple murderer Peter McCabe who sees a trip to the hospital as the perfect opportunity to get what he wants most: freedom. With McCabe's escape, the entire hospital becomes a battleground and Connor must pursue and, ironically, protect the deadly fugitive who is his son's only hope for survival.

Forensic psychologist Alex Cross travels to North Carolina and teams with escaped kidnap victim Kate McTiernan to hunt down "Casanova," a serial killer who abducts strong-willed women and forces them to submit to his demands. The trail leads to Los Angeles, where the duo discovers that the psychopath may not be working alone.

Alex Cross, a Washington D.C. cop and forensic psychologist learns that his niece who is going to college in North Carolina is missing. So he goes there and learns that the police think she's among the victims of someone who kidnaps young girls and holds them captive and kills them who dubs himself Cassanova after the great lover. Later Kate, one of his victims, escapes and tries to help Cross find his niece.