Unable to process the death of his daughter, Detective Boyd embarks on a hunt for a serial killer who murders according to a brutal tribal ritual: Muti. The only person who can help Boyd is Professor Mackles, an anthropologist who hides an unspeakable secret. The line between sanity and madness thins as Boyd goes deeper into the killer’s world.

Inspired by classic film noir, "The Poison Rose" stars John Travolta as Carson Phillips, an ex-football star turned PI, who's got a soft spot for a lady in distress. Like the classic tales spun by the masters, he takes on a routine missing persons case which slowly reveals itself to be a complex interwoven web of crimes, suspects and dead bodies. When he discovers his long lost daughter is the number one suspect, he races a ticking clock to save her, solve the murders, and uncover the town's dirty secrets.