In 1988, young sisters Katie and Kristi befriend an invisible entity called Toby, who resides in their home.

It has been five years since the disappearance of Katie and Hunter, and a suburban family witness strange events in their neighborhood when a woman and a mysterious child move in.

On the streets of New Orleans, word begins to spread about a mysterious new pill that unlocks superpowers unique to each user. The catch: You don't know what will happen until you take it. While some develop bulletproof skin, invisibility, and super strength, others exhibit a deadlier reaction. But when the pill escalates crime within the city to dangerous levels, a local cop (Joseph Gordon-Levitt) teams with a teenage dealer (Dominique Fishback) and a former soldier fueled by a secret vendetta (Jamie Foxx) to fight power with power and risk taking the pill in order to track down and stop the group responsible for creating it.