Six Los Angeles celebrities are stuck in James Franco's house after a series of devastating events just destroyed the city. Inside, the group not only have to face the apocalypse, but themselves.

The film follows a high school senior, Alex Lainey, who has an encounter with mysterious lights that appear over her small town. She soon develops dangerous, supernatural abilities and turns to her childhood friend Sean Terrel. The authorities target them and a chase ensues as officials try to discover the truth behind Alex's transformation.

High school student Neil (Jesse Carere) has vowed to remain celibate due to his religious beliefs, as his church wants him to be part of a religious ceremony that requires him to be a virgin. Neil is unaware that his church, which practices Satanism, is planning to sacrifice him to Satan in order to prevent 1000 years of peace on earth. Once Neil becomes aware of this plan, he and his best friend Matt (Daryl Sabara) make plans to find a woman to take Neil's virginity and thus save him from certain death.

Detective Hazel Micallef hasn't had much to worry about in the sleepy town of Fort Dundas until a string of gruesome murders in the surrounding countryside brings her face to face with a serial killer driven by a higher calling.