Yogi, Boo Boo and many of his friends including Huckleberry Hound, Snagglepuss, Magilla Gorilla among others decide to build an ark to look for the mythical Perfect Place which is peaceful and hasn't been affected by man and pollution. They hire the Jellystone's janitor Noah Smith to act as captain and travel throughout the world looking for such a place. Even though they think every place they land is a "Perfect place", they soon find out that there is definitely no place like home.

After solving their last mystery at Spooky Island, the Mystery Inc. gang is back in Coolsville, where they are being honored with their very own exhibit at the Coolsonian Criminology Museum. However, when a masked villain steals costumes of classic monsters on display and brings them to life, the gang must come out of retirement to solve the case.

George Jetson is forced to uproot his family when Mr. Spacely promotes him to take charge of a new factory on a distant planet.