Two criminal twin brothers, one who is trying to reform, embark on a dangerous heist road trip. Facing legal troubles, gunfights, and family drama, they must reconcile their differences before their mission leads to self-destruction.

While stuck at a wedding in Palm Springs, Nyles (Andy Samberg) meets Sarah (Cristin Milioti), the maid of honor and family black sheep. After he rescues her from a disastrous toast, Sarah becomes drawn to Nyles and his offbeat nihilism. But when their impromptu tryst is thwarted by a surreal interruption, Sarah must join Nyles in embracing the idea that nothing really matters, and they begin wreaking spirited havoc on the wedding celebration.