When it is discovered that a man is having luck in the casinos in Las Vegas, people start attempting to take his money.

Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.

A young punk recruited by a car repossession agency finds himself in pursuit of a Chevrolet Malibu that is wanted for a $20,000 bounty - and has something otherworldly stashed in its trunk.