An extremely successful dentist goes off the deep end after he catches his wife cheating on him.

Dr. Caine, the murdering dentist from the original movie, has escaped from the mental hospital where he has been since being caught. Hoping to resume a normal life, he makes his way to a quiet Midwestern town under a false name and takes on the responsibilities of the town dentist Things are starting to look up for Caine, until the day when he catches his new love in the arms of someone else. Just as in the first movie, this sends him back over the edge and into another homicidal rampage, with his unfortunate patients bearing the brunt of his hostility.

An extremely successful dentist goes off the deep end after he catches his wife cheating on him.

When saloon prostitute Cody Zamora rescues her friend Anita from an abusive customer by killing him, she is sentenced to hang. However, Anita and their two friends Eileen and Lilly rescue Cody and the four make a run for Texas, pursued by Graves and O'Brady, two Pinkerton detectives hired to track them. When Cody withdraws her savings from a Texas bank, the women believe they can now start a new life in Oregon. But Cody's old partner Kid Jarrett takes Cody's money when his gang robs the bank, and so the four so-called "Honky- Tonk Harlots" set out to recover the money, with the Pinkertons hot on their trail.