Five people spend the night in an abandoned house, an Amityville haunted house, and soon find themselves terrorized by assorted ghosts, venomous insects and ghostly apparitions.

Sam, a college student in a small Northwestern town, reluctantly joins his roommates in a contest to see who can hook up with the most gorgeous co-eds by the end of the semester. But when men slowly start disappearing around town, he and his friends learn that when it comes to beautiful women, it's what's inside that really matters.

A group of humans arrive on Sirius 6-B to investigate an SOS signal sent out from the planet, which has been supposedly deserted since the destruction of the man-made weapons known as "screamers." Once the squad arrives, they find a group of human survivors eking out an existence in an old military outpost, but more important, they discover that the threat of the screamers has become even more insidious, now that they're able to morph into human form.