An ancient urn is found in a cemetery outside Rome. Once opened, it triggers a series of violent incidents: robberies, rapes, and murders increase dramatically, while several mysterious, evil-looking young women from all over the world gather in the city. All these events are caused by the return of Mater Lacrimarum, the last of three powerful witches who have been spreading terror and death for centuries. Alone against an army of psychos and demons, Sarah Mandy, an art student who seems to have her own supernatural abilities, is the only person left to prevent the Mother of Tears from destroying Rome.

A group of tenants and visitors are trapped in a 10-story high-rise apartment building infested with demons who proceed to hunt the dwindling humans down.

A young opperata is stalked by a deranged fan bent on killing the people associated with her to claim her for himself.

Part three of the "Three Mothers" trilogy which takes place in Rome and has to do with Mater Lachrymarum (The Third Mother).