When twin brothers Bill and Hal find their father's old monkey toy in the attic, a series of gruesome deaths start. The siblings decide to throw the toy away and move on with their lives, growing apart over the years.

After being cut apart by the police, killer doll Chucky is resurrected by Tiffany, an ex-girlfriend of the serial murderer whose soul is inside the toy. Following an argument, Chucky kills Tiffany and transfers her soul into a bride doll. To find the magical amulet that can restore them both to human form, Chucky and Tiffany arrange to be driven to New Jersey by Jesse and Jade, who are unaware that their cargo is alive.

Ginger's sister Brigitte, now a werewolf herself, must try to find a cure for her blood lust before the next full moon while hiding out in a rehab clinic from a relentless werewolf.