In Freaks of Nature, we welcome you to Dillford, where three days ago, everything was peaceful and business as usual: the vampires were at the top of the social order, the zombies were at the bottom, and the humans were getting along in the middle. But this delicate balance was ripped apart when the alien apocalypse arrived in Dillford and put an end to all the harmony. Now it's humans vs. vampires vs. zombies in all-out, blood-sucking, brain-eating, vamp-staking mortal combat - and all of them are on the run from the aliens. It is up to three teenagers - one human, one vampire, and one zombie - to team up, figure out how to get rid of the interplanetary visitors, and try to restore order to this "normal" little town.

Angelenos Doug Billings and Tracy Garner are about to get married. Two days before the wedding, the four men in the wedding party - Doug, Doug's two best buddies Phil Wenneck and Stu Price, and Tracy's brother Alan Garner - hop into Tracy's father's beloved Mercedes convertible for a 24-hour stag party to Las Vegas. Phil, a married high school teacher, has the same maturity level as his students when he's with his pals. Stu, a dentist, is worried about everything, especially what his controlling girlfriend Melissa thinks. Because she disapproves of traditional male bonding rituals, Stu has to lie to her about the stag, he telling her that they are going on a wine tasting tour in the Napa Valley. Regardless, he intends on eventually marrying her, against the advice and wishes of his friends. And Alan seems to be unaware of what are considered the social graces of the western world. The morning after their arrival in Las Vegas, they awaken in their hotel suite each with the worst ...