Fox Mulder (David Duchovny) and Dana Scully (Gillian Anderson) worked at the F.B.I. as partners, a bond between them that led to them becoming lovers. But now they're out of the F.B.I. and have begun new careers. Scully works as a staff physician at a Catholic hospital. Her focus these days is on a young boy with an incurable brain disease. Administration wants to give up on him. Scully, who feels a special bond with the boy, does not. Meanwhile, Mulder's focus is on clipping newspaper articles, throwing pencils into his ceiling and writing about the paranormal. Scully and Mulder are brought together as partners again when a special case requires Mulder's expertise, and Scully is prevailed upon to convince him to help. The case involves a pedophile priest who claims he is having psychic visions regarding the whereabouts of a missing F.B.I. Agent.

Detectives Joey Moretti and Patricia Stevens are trying to track down a serial killer that preys on young attractive women, leaving only cryptic messages carved into their flesh as clues. Joey struggles to keep himself together as the investigation leads him closer and closer to the deranged killer.