Three sisters (Prue, Piper and Phoebe) reunite and unlock their powers to become the Charmed Ones, the most powerful witches to exist. Now they must vanquish evil and save innocents while living their lives as normal women in the real world. Life isn't so easy when you're Charmed.

Flight attendant Cassandra Bowden wakes in a hotel room hungover from the night before in Bangkok with a dead body lying next to her. Afraid to call the police, she continues her morning as if nothing happened. In New York, she is met by FBI agents who question her about her recent layover in Bangkok. Still unable to piece the night together, she begins to wonder if she could be the killer.

A woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.