Nothing could be worse than the sudden death of parents. One day Nick and Diana Salinger were killed in a terrible car crash, and left their five children all alone. Charlie, the oldest, Bailey, the middle brother, Julia, Claudia, and little baby Owen, who was only 6 months old when his parents died. Together, they go through all sorts of problems.

When Manhattan surgeon Andrew 'Andy' Brown is widowed, he decides to start a whole new life in the idyllic Colorado town Everwood, but gets more than he bargained for - it takes an eternity for a city-boy to fit in the small community, which already had a popular physician, and it's even worse for his unearthed kids, whom he must now parent alone: Ephram, a sensitive kid and gifted pianist, and his little sister Delia. As they all get to know Everwood people and each other better, relationships develop and change.

An extraterrestrial race arrives on Earth with seemingly good intentions, only to slowly reveal their true machinations the more ingrained into society they become