The charming and still-single Joey, who has struck out on his own and moved to Hollywood, hoping to truly make it as an actor. After reuniting with his high-strung sister Gina, Joey moves in with Michael, his 20-year-old genius nephew, who unbelievably is literally a rocket scientist. However, what Joey lacks in book smarts he makes up for with people smarts – making him the best new friend his nephew could ask for.

Episodes follows the lives of Sean and Beverly Lincoln, British sitcom producers who are persuaded to move to Hollywood and remake their series for an American audience. When the couple is forced to cast Matt LeBlanc in the lead role, a bizarre triangle is formed that strains their marriage and threatens their show.

Rachel Green, Ross Geller, Monica Geller, Joey Tribbiani, Chandler Bing and Phoebe Buffay are six 20 something year-olds, living off one another in the heart of New York City. Over the course of ten years, this average group of buddies goes through massive mayhem, family trouble, past and future romances, fights, laughs, tears and surprises as they learn what it really means to be a friend.