An undercover cop, disillusioned by the death of his wife, is implicated in the murder of an officer and must struggle to clear himself.

When car dealer Charlie Babbitt learns that his estranged father has died, he returns home to Cincinnati, where he discovers that he has a savant older brother named Raymond and that his father's $3 million fortune is being left to the mental institution in which Raymond lives. Motivated by his father's money, Charlie checks Raymond out of the facility in order to return with him to Los Angeles. The brothers' cross-country trip ends up changing both their lives.

Will Graham (William Petersen) is a former F.B.I. Agent who recently retired to Florida with his wife Molly (Kim Greist) and their young son, Kevin (David Seaman). Graham was a "profiler", one who profiles criminal's behavior and tries to put his mind into the minds of criminals to examine their thoughts while visiting crime scenes. Will is called out of his self-imposed retirement at the request of his former boss Jack Crawford (Dennis Farina) to help the F.B.I. catch an elusive serial killer, known to the press as the "Tooth Fairy" (Tom Noonan), who randomly kills whole families in their houses during nights of the full moon and leaves bite marks on his victims. To try to search for clues to get into the mind of the killer, Will has occasional meetings with Dr. Hannibal Lecktor (Brian Cox), a charismatic, but very dangerous imprisoned serial killer that Will captured years earlier which nearly drove him insane from the horrific encounter that nearly cost Will's life. With some help and hindrance, Will races against the clock before the next full moon when the "Tooth Fairy" will strike again. Elsewhere, a local photographer named Francis Dollarhyde, the killer for whom Will is looking, struggles to stay undetected while seeing a hope of redemption when be begins a relationship with a blind woman (Joan Allen) who is not aware of his double life.

In a distant future scarce of water, space pirates get caught after stealing ice from a spaceship. They are sold to a princess looking for her dad. He might have found a planet abundant with water.

When a family is held hostage, former hostage negotiator Jeff Talley arrives at the scene. Talley's own family is kidnapped and Talley must decide which is more important: saving a family he doesn't even know or saving his own family.