Unlike most television crime dramas, which neatly introduce and then solve a case all in the space of one hour, HBO's THE WIRE follows one single drug and homicide investigation throughout the length of an entire season. Centered on the drug culture of inner-city Baltimore, the series' storyline unfolds from the points of view of both the criminals lording the streets and the police officers determined to bring them down.

The Hawthornes, a prominent Boston family, are attempting to redefine themselves in the wake of a chilling discovery that links their recently deceased patriarch to a string of murders spanning decades, amid the mounting suspicions that one of them may have been his accomplice.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.