A man kisses his wife and baby goodbye and seemingly heads away on business, with a plan to check into a hotel, call an escort service, and kill an unsuspecting prostitute.

In their secluded farmhouse, a mother, formerly a surgeon in Portugal, teaches her daughter, Francisca, to understand anatomy and be unfazed by death. One afternoon, a mysterious visitor shatters the idyll of Francisca's family life, deeply traumatizing the young girl, but also awakening unique curiosities. Though she clings to her increasingly reticent father, Francisca's loneliness and scarred nature converge years later when her longing to connect with the world around her takes on a dark form.