Real estate agent Luke Roman is the owner of The Roman Agency, a boutique residential real estate brokerage specializing in "metaphysically engaged" properties, also known as haunted houses. Luke has a special connection to the spiritual realm; he can not only sense the presence that might inhabit a client's house, he can often communicate and negotiate with it. Along with his team, Luke takes on the houses nobody else can or will.

The series centers on a formerly filthy rich video store magnate Johnny Rose, his soap star wife Moira, and their two kids, über-hipster son David and socialite daughter Alexis, who suddenly find themselves broke. They are forced to live in Schitt's Creek, a small depressing town they once bought as a joke.