After their plane, Oceanic Air flight 815, tore apart whilst thousands of miles off course, the survivors find themselves on a mysterious deserted island where they soon find out they are not alone.

Project NOAH is a a secret medical facility, where scientists are experimenting with a dangerous virus that could lead to the cure for all disease, but also carries the potential to wipe out the human race. When a young girl, Amy Bellafonte, is chosen to be a test subject, Federal Agent Brad Wolgast is the man who is tasked with bringing her to Project NOAH. Ultimately, however, Wolgast becomes her surrogate father, trying to protect her at any cost. Brad and Amy’s journey will force them to confront Project NOAH’s lead scientists, Major Nichole Sykes and Dr. Jonas Lwar, as well as the hardened former Navy Operative Clark Richards, whom Brad trained. It likewise brings them face-to-face with a dangerous new race of beings confined within the walls of Project NOAH and death-row inmates. In seeking out any allies he can find, Brad also turns to his former wife for help. But as Project NOAH’s scientists hone in on a cure that could save humanity, these new beings begin to test their own powers, inching one step closer to an escape that could lead to an unimaginable apocalypse.

When nuclear Armageddon destroys civilization on Earth, the only survivors are those on the 12 international space stations in orbit at the time. Three generations later, the 4,000 survivors living on a space ark of linked stations see their resources dwindle and face draconian measures established to ensure humanity's future. Desperately looking for a solution, the ark's leaders send 100 juvenile prisoners back to the planet to test its habitability. Having always lived in space, the exiles find the planet fascinating and terrifying, but with the fate of the human race in their hands, they must forge a path into the unknown.