A psychological mystery that examines the origins of evil along the dividing line between science and religion. The series focuses on a skeptical female psychologist who joins a priest-in-training and a carpenter as they investigate the Church’s backlog of unexplained mysteries, including supposed miracles, demonic possessions, and hauntings. Their job is to assess if there is a logical explanation or if something truly supernatural is at work.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.