In Los Angeles, siblings Ellie and Jimmy come across an accident on Mulholland Drive. As they try to help the woman caught in the wreckage, a ferocious creature attacks them, devouring the woman and scratching the terrified siblings. They slowly discover that the creature was a werewolf and that they have fallen victim to a deadly curse.

Alita is a creation from an age of despair. Found by the mysterious Dr. Ido while trolling for cyborg parts, Alita becomes a lethal, dangerous being. She cannot remember who she is, or where she came from. But to Dr. Ido, the truth is all too clear. She is the one being who can break the cycle of death and destruction left behind from Tiphares. But to accomplish her true purpose, she must fight and kill. And that is where Alita's true significance comes to bear. She is an angel from heaven. She is an angel of death.