17-year-old Lisa feels certain that she inadvertently played a role in causing a traffic accident that claimed a woman's life. In her attempts to set things right, she meets with opposition at every step. Torn apart with frustration, she begins emotionally brutalizing her family, her friends, her teachers, and, most of all, herself. She has been confronted quite unexpectedly with a basic truth: that her youthful ideals are on a collision course with the realities and compromises of the adult world.

A lonely Frankenstein travels to 1930s Chicago to ask groundbreaking scientist Dr. Euphronious to create a companion for him. The two revive a murdered young woman and The Bride is born. But what ensues is beyond what either of them imagined.

In Los Angeles at the turn of the 1970s, drug-fueled detective Larry "Doc" Sportello investigates the disappearance of an ex-girlfriend.

In the 1930s, a young Bronx native moves to Hollywood, where he falls in love with the secretary of his powerful uncle, an agent to the stars. After returning to New York, he is swept up in the vibrant world of high society nightclub life.