The "two guys" are Berg and Pete who share an apartment and support themselves by delivering pizza from Beacon Street Pizza run by Bill. In the first years of medical school, Berg had a cavalier approach to life and women but now finds himself with Ashley, a fellow med student. Berg is generally happy about this relationship, but it has its ups and downs - that's what makes it so much fun. Pete has abandoned his plans to become an architect and is searching for a career Sharon is "the girl" - the upstairs neighbor who hates being a chemical saleswoman although she can't complain about the benefits, including a hefty salary and a shining "Beemer." Sharon's boyfriend Johnny adores her, but she's not sure what she wants... maybe it's because she's already met the ideal man but doesn't know it. For now, she enjoys being part of a special threesome enjoying life no matter how unbelievable it can really be.

In the high-tech gold rush of modern Silicon Valley, the people most qualified to succeed are the least capable of handling success. A comedy partially inspired by Mike Judge's own experiences as a Silicon Valley engineer in the late 1980s.