In the town of Fairview there's a street called Wisteria Lane; a peaceful cul-de-sac with manicured lawns and beautiful houses. It's a place where you know all your neighbors and your neighbors know all about you. It's the perfect suburban fantasy. But, behind every picket fence there are secrets. And, in every seemingly happy home, you'll find jealousy, lust, passion, and sometimes... murder.

When Manhattan surgeon Andrew 'Andy' Brown is widowed, he decides to start a whole new life in the idyllic Colorado town Everwood, but gets more than he bargained for - it takes an eternity for a city-boy to fit in the small community, which already had a popular physician, and it's even worse for his unearthed kids, whom he must now parent alone: Ephram, a sensitive kid and gifted pianist, and his little sister Delia. As they all get to know Everwood people and each other better, relationships develop and change.