True Blood is based on The Southern Vampire Mysteries series of novels by Charlaine Harris, detailing the co-existence of vampires and humans in Bon Temps, a fictional, small town in northwestern Louisiana. The series centers on the adventures of Sookie Stackhouse (Anna Paquin), a telepathic waitress with an otherworldly quality.

In the town of Fairview there's a street called Wisteria Lane; a peaceful cul-de-sac with manicured lawns and beautiful houses. It's a place where you know all your neighbors and your neighbors know all about you. It's the perfect suburban fantasy. But, behind every picket fence there are secrets. And, in every seemingly happy home, you'll find jealousy, lust, passion, and sometimes... murder.

Twenty-four-year-old Kara Zor-El, who was taken in by the Danvers family when she was 13 after being sent away from Krypton, must learn to embrace her powers after previously hiding them. The Danvers teach her to be careful with her powers, until she has to reveal them during an unexpected disaster, setting her on her journey of heroism.