The charming and still-single Joey, who has struck out on his own and moved to Hollywood, hoping to truly make it as an actor. After reuniting with his high-strung sister Gina, Joey moves in with Michael, his 20-year-old genius nephew, who unbelievably is literally a rocket scientist. However, what Joey lacks in book smarts he makes up for with people smarts – making him the best new friend his nephew could ask for.

Two hundred years in the future, in a fully colonized solar system, police detective Josephus Miller is given the assignment to find a missing young woman, Julie Mao. Joining his task is James Holden, former first officer of an ice freighter who is involved in an incident caused by the tense relationship between Earth, Mars and the Belt. Far from their struggles in space, United Nations executive Chrisjen Avasarala works to prevent war between Earth and Mars. Soon the three find out that the missing woman is connected to a vast conspiracy that threatens all humanity.