The Spengler family returns to where it all started – the iconic New York City firehouse – to team up with the original Ghostbusters, who've developed a top-secret research lab to take busting ghosts to the next level. But when the discovery of an ancient artifact unleashes an evil force, Ghostbusters new and old must join forces to protect their home and save the world from a second Ice Age.

Mitch Taylor is one of the youngest students ever accepted to a university known for its programs for geniuses. He partners up with his roommate, science club legend Chris Knight, on a project to develop a high-powered laser. Together with their hyperkinetic friends, they employ their intellects in the pursuit of bigger blasts, practical jokes, and a deeper understanding of what real genius means. When they find out that their professor intends to turn their work over to the military for use as a weapon, they decide to get even.