"Left Behind" finds commercial airline pilot Ray Steele (Nicholas Cage) struggling to keep his passengers calm and his plane afloat after the Biblical Rapture strikes mid-flight. Meanwhile, GWN reporter Cameron "Buck" Williams (Chad Michael Murray) becomes Ray's reluctant co-pilot, and Ray's terrified daughter Chloe (Cassi Thomson) braves the chaos of the city streets in search of her brother and mother.

Elliot Brindle is a bright, meek salesman, drowning in debt - and desperate as he's about to marry the love of his life. Upon receiving a phone call informing him that he's on a hidden camera game show where he must execute 13 tasks to receive a sum total cash prize of $6.2M, Elliot dismissively follows through with his first two instructions: swat the fly that is currently bothering him, then eat the fly. With thousands of dollars suddenly appearing in his bank account, Elliot remains skeptical, though comforted by the knowledge that he can stop playing at anytime if only to lose every penny that he's won. Trapped into the horrors manipulated by unseen spectators, Elliot's need to complete the game escalates as the tasks grow more extreme, to a devastating point of no return.