Framed by their ruthless arch-nemesis, a pair of mismatched LAPD officers must put their differences aside to get even with the brutal crime baron who sent them to rot in a maximum-security prison.

Four college pledges are forced to spend the night in a deserted old mansion, where they are stalked by the monstrous survivor of a family massacre years earlier.

Framed by their ruthless arch-nemesis, a mismatched LAPD crime-fighting duo has to put its differences aside to even the score with the evil kingpin who put them behind bars once and for all.

Ray Tango and Gabriel Cash are narcotics detectives who, while both being extremely successful, can't stand each other. Crime Lord Yves Perret, furious at the loss of income that Tango and Cash have caused him, frames the two for murder. Caught with the murder weapon at the scene of the crime, the two have no alibi. Thrown into prison with most of the criminals they helped convict, it appears that they are going to have to trust each other if they are to clear their names and catch the evil Perret.