A much more lavish version of the popular Superman television series which had first aired forty years earlier, Lois & Clark focused more on the Man of Steel's early adult years in Metropolis. With the unknowing help of Lois Lane, Clark Kent created Superman there in Metropolis after finding work at the world-famous Daily Planet newspaper, where he meets fellow reporter Lois Lane.

In the town of Fairview there's a street called Wisteria Lane; a peaceful cul-de-sac with manicured lawns and beautiful houses. It's a place where you know all your neighbors and your neighbors know all about you. It's the perfect suburban fantasy. But, behind every picket fence there are secrets. And, in every seemingly happy home, you'll find jealousy, lust, passion, and sometimes... murder.

Charlie is a well-to-do bachelor with a house at the beach, a Jaguar in the front, and an easy way with women. His casual Malibu lifestyle is interrupted when his tightly wound brother Alan, who's facing a divorce, and his son Jake, come to live with him. Together, these two and a half men confront the challenges of growing up; finally. Complicating matters are the brothers' self-obsessed, controlling mother, Evelyn, Alan's estranged wife, Judith and Charlie's crazy neighbor Rose, who wants to be a part of his life and is willing to do anything to be around. After the death of his brother, Alan Harper meets and befriends a lonely young man named Walden Schmidt who turns out to be a billionaire. Unable to afford his brother's home, Alan sells Walden the house, and as a way of showing his gratitude, Walden allows Alan and his son Jake to move in with him.